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职称/职务 Academic title/Position:
病毒学国家重点实验室,教授、主任。Professor and Director, State Key Laboratory of Virology.
武汉生物技术研究院,副院长。Vive President, Wuhan Institute of Biotechnology.
研究领域 Research Field:微生物学/病毒学 Microbiology/Virology
研究方向 Research Interests:
病毒感染与致病的分子机理。Molecular Mechanisms of Viral Infection and Pathogenesis.
病毒病与肿瘤诊断和防治新技术。New Approaches to the Prevention and Treatment of Viral Diseases and Cancers.


学习经历 Education:
1993-1996:美国普林斯顿大学,分子生物学,博士后。Postdoctoral Associate in Molecular Biology, Princeton University, NJ, USA.
1989-1992:美国爱达华大学,生物化学,博士。Ph.D. in Biochemistry, University of Idaho, ID, USA.
1982-1985:yabo亚搏官方网站,病毒学,硕士。M.S. in Virology, Wuhan University, Wuhan, China.
1978-1982:yabo亚搏官方网站,微生物学,学士。B.S. in Microbiology, Wuhan University, Wuhan, China.

工作经历 Work Experience:

2010-至今:武汉生物技术研究院,副院长。Vice President, Wuhan Institute of Biotechnology, Wuhan, China.
2005-至今:病毒学国家重点实验室,主任。Director, State Key Laboratory of Virology, Wuhan, China.
1999-至今:yabo亚搏官方网站,教授、博士生导师。Professor and Doctoral Supervisor, College of Life Sciences, Wuhan University, Wuhan, China.
1996-1999:美国普林斯顿大学,研究员。Research Staff Member, Princeton University, NJ, USA.
1992-1993:美国爱达华大学,副研究员。Research Associate, University of Idaho, ID, USA.
1986-1989:美国佐治亚大学,访问学者。Visiting Scholar, University of Georgia, GA, USA.
1985-1986:yabo亚搏官方网站,讲师。Lecturer, Wuhan University, Wuhan, China.

学术兼职 Committee and Broad Memberships:
1. 病毒学国家重点实验室学术委员会,副主任委员。Vice President, Broad Committee, State Key Laboratory of Virology.
2. 农业微生物国家重点实验室学术委员会,副主任委员。Vice President, Broad Committee, State Key Laboratory of Agricultural Microbiology.
3. 湖北省生物工程学会,理事长。President, Hubei Society for Biotechnology.
4. 湖北省微生物学会,副理事长。Vice President, Hubei Society for Microbiology.
5. 中国生物工程学会,理事。Broad Member, Chinese Society for Microbiology.
6. 中国微生物学会病毒专业委员会,理事。Broad Member, Division of Virology in Chinese Society for Microbiology.

科研项目 Research Grants and Funding:
主持国家科技重大专项、国家科技部973计划项目、国家自然科学基金重点项目等多项。Principle Investigator for multiple grants from the Ministry of Science and Technology of China, National Science Foundation of China.

代表性学术论文 Selected Publications (62 out of 118):

1. Chen YN, Chen JB, Wang H, Shi JJ, Wu KL, Liu S, Liu YL, Wu JG (2013). HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1. PLoS Pathog 9(4):e1003248. (IF:9.629)

2. Xia C, Chen YC, Gong H, Zeng WB, Vu GP, Trang P, Lu SW, Wu JG, Liu FY (2013). Inhibition of hepatitis B virus gene expression and replication by ribonuclease P. Mol Ther 21(5):995-1003. (IF:6.284)
3. Cao YH, Zhang W, Yu Y, Zhu CL, Zhang R, Song Y, Wang Q, Bai L, Liu YL, Wu KL, Wu JG (2013). IL-27, a cytokine, and IL-29, a type III interferon, are coordinated to regulate virus replication in a manner similar to type I interferon. J Immunol (Accepted) (IF:5.745)
4. Xu P, Huang ZX, Gao XD, Michel FJ, Hirsch G, Hogan RJ, Sakamoto K, Ho WZ, Wu JG, He B (2013). Infection of mice, ferrets, and rhesus macaques with a clinical mumps virus isolate. J Virol 87(14):8158-8168. (IF:5.189)
5. Yu Y, Cao YH, Sun ZC, Zhang W, Wu KL, Wu JG (2013). Hepatitis B e antigen activates the suppressor of cytokine signaling-2 to antagonize type I and type III interferon and mediate viral immune evasion. Eur J Immunol (In reversion) (IF:4.970)
6. Zhang Z, Vu GP, Gong H, Xia C, Chen YC, Liu FY, Wu JG, Lu SW (2013). Engineered external guide sequences are highly effective in inhibiting gene expression and replication of hepatitis B virus in cultured cells. PLoS One 8(6):e65268. (IF:4.411)
7. Liu S, Hao Q, Wang Y, Yue X, Peng NF, Chen YN, Wu JG, Zhu Y (2012). Major vault protein: A virus-induced host factor against viral replication through the induction of type-I interferon. Hepatology 56(1):57-66. (IF:11.665)
8. Yue X, Wang H, Zhao F, Liu S, Wu JG, Ren W, Zhu Y (2012). Hepatitis B virus-induced calreticulin protein is involved in interferon resistance. J Immunol 189(1):279-286. (IF:5.745)
9. Liu L, Cao ZY, Chen J, Li R, Cao YH, Zhu CL, Wu KL, Wu JG, Liu F, Zhu Y (2012). Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. J Biol Chem 287(15):11899-11910. (IF:5.328)
10. Li YX, Zhang Q, Liu Y, Luo Z, Kang L, Qu J, Liu WY, Xia XS, Liu YL, Wu KL, Wu JG (2012). Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways. J Virol 86(23):12531-12543. (IF:5.189)
11. Zhang Q, Gong R, Qu J, Zhou YJ, Liu WY, Chen MZ, Liu YL, Zhu Y, Wu JG (2012). Activation of the Ras/Raf/MEK pathway facilitates HCV replication via attenuation of the INF-JAK-STAT pathway. J Virol 86(3):1544-1554. (IF:5.189)
12. Fang JL, Liu L, Li YK, Wu JG, Huo XX, Zhu Y (2012). Epigenetic changes mediated by miR29 activate cyclooxygenase-2 and interferon-1 production during viral infection. J Virol 86(2):1010-1020. (IF:5.189)
13. Xu P, Luthra PY, Li Z, Fuentes S, D’Andrea J, Wu JG, Rubin S, Rota P, He B (2012). The V protein of mumps virus plays a critical role in pathogenesis. J Virol 86(3):1768-1776. (IF:5.189)
14. Zeng WB, Chen YC, Bai Y, Trang P, Vu GP, Lu SW, Wu JG, Liu FY (2012). Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme. PLoS One 7(12):e51855. (IF:4.411)
15. Li CW, Yu S, Zhong XL, Wu JG, Li XD (2012). Circadian rhythms of fetal liver transcription persist in the absence of canonical circadian clock gene expression rhythms in vivo. PLoS One 7(2): e30781. (IF:4.411)
16. Li CW, Yu S, Zhong XL, Wu JG, Li XD (2012). Transcriptome comparison between fetal and adult mouse livers: Implications for circadian clock mechanisms. PLoS One 7(2): e31292. (IF:4.411)
17. Chen YN, Shen A, Rider PJ, Yu Y, Wu KL, Mu YX, Hao Q, Liu YL, Gong H, Zhu Y, Liu FY, Wu JG (2011). A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication. FASEB J 25(12):4511-4521. (IF:6.515)
18. Yu Y, Gong R, Mu YX, Chen YN, Zhu CL, Sun ZC, Chen MZ, Liu YL, Zhu Y, Wu JG (2011). Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, interleukin-29, interleukin-8, and cyclooxygenase-2. J Immunol 187(9):4844-4860. (IF:5.745)
19. Liu QY, Chen JW, Liu L, Zhang J, Wang DF, Ma L, He YM, Liu YL, Liu ZS, Wu JG (2011). The X protein of HBV inhibits apoptosis in hepatoma cells through enhancing MAT2A expression and reducing SAM production. J Biol Chem 286(19):17168-17180. (IF:5.328)
20. Liu QY, Liu L, Zhao YH, Zhang J, Wang DF, Chen JW, He YM, Wu JG, Zhang ZL, Liu ZS (2011). Hypoxia induces genomic DNA demethylation through the activation of HIF-1a and transcriptional up-regulation of MAT2A in hepatoma cells. Mol Cancer Ther 10(6):1113-1123. (IF:5.225)
21. Liu MY, Liu WY, Luo J, Liu YL, Zhu Y, Berman H, Wu JG (2011). Characterization of an outbreak of hand, foot, and mouth disease in Nanchang, China in 2010. PLoS One 6(9): e25287. (IF:4.411)
22. Qu J, Yang ZH, Zhang Q, Liu WY, Li YX, Ding Q, Liu F, Liu YL, Pan ZS, He B, Zhu Y, Wu JG (2011). Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by direct targeting HCV 5’-untranslated region. FEBS Lett 585(24):4002-4009. (IF:3.601)
23. Luo M, Qu X, Pan R, Zhu D, Zhang Y, Wu JG, Pan ZS (2011). The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice. Vaccine 29(14):2561-2567. (IF:3.572)
24. Xu P, Li Z, Sun DY, Lin Y, Wu JG, Rota P, He B (2011). Rescue of wild-type mumps virus from a strain associated with recent outbreaks helps to define the role of the SH ORF in the pathogenesis of mumps virus. Virology 417(1):126-136. (IF:3.305)
25. Li W, Sun W, Liu L, Yang F, Li Y, Chen Y, Fang J, Zhang W, Wu JG, Zhu Y (2010). IL-32: A host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. J Immunol 185(9):5056-5065. (IF:5.745)
26. Li W, Yang F, Liu Y, Gong R, Liu L, Feng Y, Hu P, Sun W, Hao Q, Kang L, Wu JG, Zhu Y (2009). Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. Eur J Immunol 39(4):1019-1024. (IF:4.942)
27. Mukhtar MM, Li SF, Li W, Wan T, Mu YX, Wei W, Kang L, Rasool ST, Xiao YB, Zhu Y, Wu JG (2009). Single-chain intracellular antibodies inhibit influenza virus replication by disrupting interaction of proteins involved in viral replication and transcription. Int J Biochem Cell Biol 41(3):554-560. (IF:4.956)
28. Zhu CL, Zhang R, Liu L, Rasool ST, Mu YX, Sun W, Hao Q, Liu F, Zhu Y, Wu JG (2009). Hepatitis B virus enhances interleukin-27 expression both in vivo and in vitro. Clin Immunol 131(1):92-97. (IF:3.932)
29. Xia LM, Huang WJ, Wu JG, Yang YB, Zjang Q, Zhou ZZ, Zhu HF, Lei P, Shen GX, Tian GA (2009). HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-kappaB. Virology 385(2):335-342. (IF:3.305)
30. Peng GQ, Yan Y, Zhu CL, Wang SQ, Yan XH, Lu LL, Li W, Hu J, Wei W, Mu YX, Chen YN, Feng Y, Gong R, Wu KL, Zhang FM, Zhang XL, Zhu Y, Wu JG (2008). Borna disease virus P protein affects neural transmission through interacting with gamma-aminobutyric acid receptor-associated protein. J Virol 82 (24):12487-12497. (IF:5.189)
31. Wang K, Zhang Y, Li X, Chen L, Wang H, Wu JG, Zheng J, Wu D (2008). Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem 283(34):23371-23375. (IF:5.328)
32. Lu LL, Wei L, Peng GQ, Mu YX, Wu KL, Kang L, Yan XH, Zhu Y, Wu JG (2008). NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. Virology 371:61-70. (IF:3.305)
33. Feng Y, Wang SQ, Luo FL, Ruan Y, Kang L, Xiang XH, Peng GQ, Zhu CL, Mu YX, Zhang XL, Wu JG (2008). A novel recombinant bacterial vaccine strain expressing dual viral antigens induces multiple immune responses to the gag and gp120 proteins of HIV-1 in immunized mice. Antivir Res80:272-279. (IF:4.439)
34. Li W, Liu Y, Mukhtar MM, Gong R, Pan Y, Rasool ST, Gao Y, Kang L, Hao Q, Peng GQ, Chen YN, Chen X, Wu JG, Zhu Y (2008). Activation of interleukin-32 proinflammatory pathway in response to influenza A virus infection. PLoS One 3(4):e1985. (IF:4.411)
35. Liu M, Yang YB, Gu CF, Yue YP, Wu KK, Wu JG, Zhu Y (2007). Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via both calcium-dependent and calcium-independent protein kinase C pathways. FASEB J 21(7):1586-1596. (IF:6.515)
36. Peng GQ, Zhang FM, Zhang Q, Wu KL, Zhu F, Wu JG (2007). Borna disease virus P protein inhibits nitric oxide synthase gene expression in astrocytes. Virology 366:446-452. (IF:3.305)
37. Zhang X, Wu KL, Wang D, Yue X, Song DG, Zhu Y, Wu JG (2007). Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB. Virology 365(2):324-335. (IF:3.305)
38. Li PF, Wan Q, Feng Y, Liu M, Wu JG, Chen XW, Zhang XL (2007). Engineering of N-glycosylation of hepatitis C virus envelope protein E2 enhances T cell responses for DNA immunization. Vaccine 25:1544-1551. (IF:3.572)
39. Wu KL, Mu YX, Hu J, Lu L, Zhang X, Yang YB, Li Y, Liu F, Song DG, Zhu Y, Wu JG (2007). Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system. Antivir Res 74:142-149. (IF:4.439)
40. Mukhtar MM, Rasool ST, Song D, Zhu CL, Hao Q, Zhu Y, Wu JG (2007). Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses. J Gen Virol 88:3094-3099. (IF:3.568)
41. Yan XH, Hao Q, Mu YX, Timani KT, Ye LB, Zhu Y, Wu JG (2006). Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein. Int J Biochem Cell Biol38(8):1417-1428. (IF:4.956)
42. Huang WJ, Liu ZC, Wei W, Wang GH, Wu JG, Zhu F (2006). Human endogenous retroviral pol RNA and protein detected and identified in the blood of individuals with schizophrenia. Schizophr Res 83(2-3):193-199. (IF:4.374)
43. Wei W, Huang WJ, Pan Y, Zhu F, Wu JG (2006). Functional switch of viral protein HBx on cell apoptosis, transformation, and tumorigenesis in association with oncoprotein Ras. Cancer Lett 244(1):119-128. (IF:4.864)
44. Ecker DJ, Sampath R, Blyn LB, Eshoo MW, Ivy C, Ecker JA, Libby B, Samant V, Sannes-Lowery KA, Melton RE, Russell K, Freed N, Barrozo C, Wu JG, et al. (2005). Rapid identification and strain typing of respiratory pathogens for epidemic surveillance. Proc Natl Acad Sci USA102(22):8012-8017. (IF:9.771)
45. Crum NF, Russell KL, Kaplan EL, Wallace MR, Wu JG, Ashtari P, Morris DJ, Hale BR (2005). Pneumonia outbreak associated with group a Streptococcus species at a military training facility. Clin Infect Dis 40(4):511-518. (IF:8.161)
46. Pan Q, Zhang XL, Wu HY, He PW, Wang F, Zhang MS, Hu JM, Xia B, Wu JG (2005). Aptamers that preferentially bind type IVB pili and inhibit human monocytic-cell invasion by Salmonella enterica serovar typhi. Antimicrob Agents Ch 49(10):4052-4060. (IF:4.672)
47. Metzgar D, Osuna M, Yingst S, Rakha M, Earhart K, Elyan D, Esmat H, Saad MD, Kajon A, Wu JG, Gray GC, Ryan MA, Russell KL (2005). PCR analysis of egyptian respiratory adenovirus isolates, including identification of species, serotypes, and coinfections. J Clin Microbiol43(11):5743-5752. (IF:4.220)
48. Sun G, Guo M, Shen A, Mei F, Peng X, Gong R, Guo DY, Wu JG, Tien P, Xiao GF (2005). Bovine PrPC directly interacts with alphaB-crystalline. FEBS Lett 579:5419-5424. (IF:3.601)
49. Wang F, Zhang XL, Zhou Y, Ye LB, Qi ZT, Wu JG (2005). Type IVB piliated Salmonella typhi enhance IL-6 and NF-kappaB production in human monocytic THP-1 cells through activation of protein kinase C. Immunobiology 210:283-293. (IF:4.114)
50. Blasiole D, Metzgar D, Daum L, Ryan M, Wu JG, Wills C, Le C, Freed NE, Hansen C, Gray G, Russell KL (2004). Molecular analysis of adenovirus isolates from vaccinated and unvaccinated young adults. J Clin Microbiol 42 (4):1686-1693. (IF:4.220)
51. Wu JG, Ohta N, Zhao J, Newton A (1999). A novel bacterial tyrosine kinase essential for cell division and differentiation. Proc Natl Acad Sci USA 96:13068-13073. (IF:9.771)
52. Wu JG, Ohta N, Newton A (1998). An essential, multi-component signal transduction pathway required for cell cycle regulation in Caulobacter. Proc Natl Acad Sci USA 95:1443-1448. (IF:9.771)
53. Wu JG, Miller BL (1997). Aspergillus asexual reproduction and sexual reproduction are differentially affected by transcriptional and translational mechanisms regulating stunted gene expression. Mol Cell Biol 17:6191-6201. (IF:6.188)
54. Wu JG, Ohta N, Benson AK, Ninfa A, Newton A (1997). Purification, characterization, and reconstitution of DNA-dependent RNA polymerases from Caulobacter crescentus. J Biol Chem 272:21558-21564. (IF:5.328)
55. Wu JG, Newton A (1997). Regulation of the Caulobacter flagellar gene hierarchy; not just for motility. Mol Microbiol 24:33-239. (IF:4.819)
56. Wu JG, Newton A (1997). The Caulobacter heat shock sigma factor gene rpoH is positively autoregulated from a sigma32-dependent promoter. J Bacteriol 179:514-521. (IF:3.726)
57. Wu JG, Newton A (1996). Isolation, identification, and transcriptional specificity of the heat shock sigma factor sigma32 from Caulobacter crescentus. J Bacteriol 178:2094-2101. (IF:3.726)
58. Wu JG, Benson AK, Newton A (1995). Global regulation of a sigma54-dependent flagellar gene family in Caulobacter crescentus by the transcription activator FlbD. J Bacteriol 177:3241-3250. (IF:3.726)
59. Miller KY, Wu JG, Miller BL (1992). StuA is required for cell pattern formation in Aspergillus. Gene Dev 6:1770-1782. (IF:12.889)
60. Wu JG, Miller LK (1989). Sequence, transcription, and translation of a late gene of the Autographa californica nuclear polyhedrosis virus encoding a 34.8K polypeptide. J Gen Virol 70:2449-2459. (IF:3.368)
61. Tomalski MD, Wu JG, Miller LK (1988). The location, sequence, transcription, and translation of a baculovirus DNA polymerase gene. Virology 167:591-600. (IF:3.305)

62. Wu JG, Lu WJ, Tien P (1986). Multiplication of Velvet tobacco mottle virus in Nocotiana clevelandii protoplasts is resistant to alpha-Amanitin. J Gen Virol 67:2757-2762. (IF:3.368)

部分奖励及荣誉 Selected Awards and Honors:

联系方式/Contact Information:

电话/Tel: 86-27-68754979 (O); 86-27-68754600 (Lab)
传真/Fax: 86-27-68754592
电子邮箱/E-mail: jwu@whu.edu.cn